HIGH-GRADE CERVICAL LESIONS AMONG WOMEN ATTENDING A REFERENCE CLINIC IN BRAZIL: ASSOCIATED FACTORS AND COMPARISON AMONG SCREENING METHODS.

High-grade cervical lesions among women attending a reference clinic in Brazil: associated factors and comparison among screening methods.

Although screening for cervical cancer is recommended for women in most countries, the incidence of cervical cancer is greater in developing countries.Our goal was to determine the prevalence and factors associated with high-grade lesions/cervical cancer among women attending a reference clinic in Brazil and evaluate the correlation of histology wi

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First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

Background: We conducted a first-in-human dose-escalation study with the oral FASN inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as monotherapy and with a taxane.Methods: This completed open-label outpatient study was conducted at 11 sites in the United States and United Kingdom.Patients with

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